And lastly, clonidine improves neuraxial opioids and, together with fentanyl, interacts within an additive manner, which may lessen the dose of every part by 60% for postoperative analgesia. Clonidine treats large blood pressure level by stimulating α2 receptors during the brainstem, which decreases peripheral vascular resistance, decreasing blood pressure. https://letsbookmarkit.com/story19707249/onolidine-options