Inside the LSD-bound crystal composition, the aspect chain in the lid residue L209EL2 forms intensive hydrophobic contacts with both of those LSD and surrounding residues in TMs III, IV, and V (Determine 4C). If the lid moved aside to reveal the binding pocket in simulation, several of such contacts broke. https://elliottpanm.total-blog.com/indicators-on-lsd-aztec-99-you-should-know-60339462