Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals from the microenvironment and escalating the activation of anti-apoptotic and proliferation pathways.31,32 Genomic experiments have determined recurrent mutations in genes regulating tumor mobile-microenvironment interactions... https://angelinaj208dlu6.blazingblog.com/profile