Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts with the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific tests have identified recurrent mutations in genes regulating tumor cell-microenvironment interactions, ... https://franki207ahp4.rimmablog.com/profile