Chemotherapy was potentiated by E7449 and solitary agent had important antitumor action in BRCA-deficient xenografts. Additionally, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, probably by way of TNKS inhibition. According to this risk, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and considerably altered expression of Wnt https://abbiea974sxb8.ssnblog.com/profile