Substitution at R3 using a halogen or alkoxy group (74f–74i) resulted in a slight boost in mobile potency with the halide analogs (74g–h) displaying optimum the potency during the group. Further optimization led to the invention of 74i–j, with 74k as the most Energetic compound from the sequence (pIC50 = https://jasperbwods.kylieblog.com/31963573/5-simple-statements-about-indazole-amide-explained